Susceptibilities of Neisseria gonorrhoeae Isolates Containing Amino Acid Substitutions in GyrA, with or without Substitutions in ParC, to Newer Fluoroquinolones and Other Antibiotics-Reference-Cited by-同舟云学术

Susceptibilities of Neisseria gonorrhoeae Isolates Containing Amino Acid Substitutions in GyrA, with or without Substitutions in ParC, to Newer Fluoroquinolones and Other Antibiotics

Published:2000-01 Issue:1 Volume:44 Page:192-195
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Tanaka Masatoshi¹,Nakayama Hiroshi²,Haraoka Masashi¹,Saika Takeshi³,Kobayashi Intetsu³,Naito Seiji¹

Affiliation:

1. Department of Urology, Faculty of Medicine, Kyushu University,1 and

2. Nakayama Urologic Clinic,2 Fukuoka, and

3. Chemotherapy Division, Mitsubishi-kagaku BCL, Tokyo,3 Japan

Abstract

ABSTRACT We examined the antimicrobial susceptibilities of 85 Neisseria gonorrhoeae isolates, classified according to the presence of amino acid substitutions in the GyrA and ParC proteins, to 12 fluoroquinolones and 7 other antibiotics. Sitafloxacin and HSR-903 showed excellent activity against N. gonorrhoeae , including strains with both GyrA and ParC substitutions. Among the strains with various GyrA substitutions, strains with a serine-91-to-phenylalanine mutation required the highest MICs of all of the fluoroquinolones tested and were cross-resistant to structurally unrelated β-lactams.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.44.1.192-195.2000

Reference11 articles.

1. Neisseria gonorrhoeae acquires mutations in analogous regions of gyrA and parC in fluoroquinolone-resistant isolates.;Belland R. J.;Mol. Microbiol.,1994

2. Quinolone-resistant Neisseria gonorrhoeae: correlation of alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV with antimicrobial susceptibility profiles

3. Antimicrobial resistance in Neisseria gonorrhoeae in the United States, 1988–1994: the emergence of decreased susceptibility to the fluoroquinolones.;Fox K. K.;J. Infect. Dis.,1997

4. Gonococcal Resistance to β-Lactams and Tetracycline Involves Mutation in Loop 3 of the Porin Encoded at the penB Locus

5. Transcriptional control of the mtr efflux system of Neisseria gonorrhoeae

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