Staphylococcus aureus Isolated from Skin from Atopic-Dermatitis Patients Produces Staphylococcal Enterotoxin Y, Which Predominantly Induces T-Cell Receptor Vα-Specific Expansion of T Cells-Reference-Cited by-同舟云学术

Staphylococcus aureus Isolated from Skin from Atopic-Dermatitis Patients Produces Staphylococcal Enterotoxin Y, Which Predominantly Induces T-Cell Receptor Vα-Specific Expansion of T Cells

Published:2020-01-22 Issue:2 Volume:88 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Aziz Fatkhanuddin¹²,Hisatsune Junzo¹³,Yu Liansheng¹³,Kajimura Junko⁴,Sato’o Yusuke⁵,Ono Hisaya K.⁶,Masuda Kanako¹,Yamaoka Mika⁴,Salasia Siti Isrina Oktavia⁷,Nakane Akio⁸,Ohge Hiroki⁹,Kusunoki Yoichiro⁴,Sugai Motoyuki¹³

Affiliation:

1. Department of Bacteriology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

2. Animal Health Study Program, Department of Bioresources Technology and Veterinary, Vocational College, University of Gadjah Mada, Yogyakarta, Indonesia

3. Antimicrobial Resistance Research Center, National Institute of Infectious Diseases, Tokyo, Japan

4. Department of Molecular Biosciences, Radiation Effects Research Foundation, Hiroshima, Japan

5. Division of Bacteriology, Department of Infection and Immunity, School of Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan

6. Laboratory of Zoonoses, Kitasato University School of Veterinary Medicine, Towada, Aomori, Japan

7. Department of Clinical Pathology, Faculty of Veterinary Medicine, University of Gadjah Mada, Yogyakarta, Indonesia

8. Department of Microbiology and Immunology, Hirosaki University, Aomori, Japan

9. Department of Infectious Diseases, Hiroshima University Hospital, Hirsohima, Japan

Abstract

While investigating the virulence traits of Staphylococcus aureus adhering to the skin of atopic-dermatitis (AD) patients, we identified a novel open reading frame (ORF) with structural similarity to a superantigen from genome sequence data of an isolate from AD skin. Concurrently, the same ORF was identified in a bovine isolate of S. aureus and designated SElY (H. K. Ono, Y. Sato’o, K. Narita, I.

Funder

Japan Agency for Medical Research and Development

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00360-19

Reference53 articles.

1. Food Poisoning and Staphylococcus aureus Enterotoxins

2. The bacterial superantigen and superantigen-like proteins

3. The Evaluation and Management of Toxic Shock Syndrome in the Emergency Department: A Review of the Literature