Caspase-1 and Caspase-11 Mediate Pyroptosis, Inflammation, and Control of Brucella Joint Infection-Reference-Cited by-同舟云学术

Caspase-1 and Caspase-11 Mediate Pyroptosis, Inflammation, and Control of Brucella Joint Infection

Published:2018-09 Issue:9 Volume:86 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Lacey Carolyn A.¹²,Mitchell William J.¹,Dadelahi Alexis S.¹²,Skyberg Jerod A.¹²^ORCID

Affiliation:

1. Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, Missouri, USA

2. Laboratory for Infectious Disease Research, University of Missouri, Columbia, Missouri, USA

Abstract

Brucellosis, caused by the intracellular bacterial pathogen Brucella , is a zoonotic disease for which arthritis is the most common focal complication in humans. Here we investigated the role of inflammasomes and their effectors, including interleukin-1 (IL-1), IL-18, and pyroptosis, on inflammation and control of infection during Brucella -induced arthritis.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

University of Missouri

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00361-18

Reference65 articles.

1. The new global map of human brucellosis

2. Osteoarticular complications of brucellosis.