Pseudomonas aeruginosa Infection Impairs NKG2D-Dependent NK Cell Cytotoxicity through Regulatory T-Cell Activation-Reference-Cited by-同舟云学术

Pseudomonas aeruginosa Infection Impairs NKG2D-Dependent NK Cell Cytotoxicity through Regulatory T-Cell Activation

Published:2020-11-16 Issue:12 Volume:88 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Vourc’h Mickael¹²^ORCID,David Gaelle³⁴⁵,Gaborit Benjamin¹,Broquet Alexis¹^ORCID,Jacqueline Cedric¹^ORCID,Chaumette Tanguy¹^ORCID,Caillon Jocelyne¹,Roquilly Antoine¹²,Retiere Christelle³⁴⁵,Asehnoune Karim¹²

Affiliation:

1. Université de Nantes, Thérapeutiques Cliniques et Expérimentales des Infections, EA 3826, Institut de Recherche en Santé 2 Nantes Biotech, Nantes, France

2. Intensive Care Unit, Anesthesia and Critical Care Department, Hôtel Dieu, University Hospital of Nantes, Nantes, France

3. Etablissement Français du Sang, Nantes, France

4. Université de Nantes, INSERM U1232 CNRS, CRCINA, Nantes, France

5. LabEx IGO “Immunotherapy, Graft, Oncology,” Nantes, France

Abstract

Natural killer (NK) cells play a key role in both antibacterial and antitumor immunity. Pseudomonas aeruginosa infection has already been reported to alter NK cell functions. We studied in vitro the effect of P. aeruginosa on NK cell cytotoxic response (CD107a membrane expression) to a lymphoma cell line. Through positive and negative cell sorting and adoptive transfer, we determined the influence of monocytes, lymphocytes, and regulatory T cells (Treg) on NK cell function during P. aeruginosa infection.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00363-20

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