Perifosine Mechanisms of Action in Leishmania Species-Reference-Cited by-同舟云学术

Perifosine Mechanisms of Action in Leishmania Species

Published:2017-04 Issue:4 Volume:61 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

López-Arencibia Atteneri¹²,Martín-Navarro Carmen²,Sifaoui Ines³,Reyes-Batlle María²,Wagner Carolina²⁴,Lorenzo-Morales Jacob²,Maciver Sutherland K.¹,Piñero José E.²

Affiliation:

1. Centre for Integrative Physiology, Biomedical Sciences, Edinburgh Medical School, University of Edinburgh, Edinburgh, United Kingdom

2. University Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Canary Islands, Spain

3. Laboratoire Matériaux-Molécules et Applications, University of Carthage, La Marsa, Tunisia

4. Cátedra de Parasitología, Escuela de Bioanálisis, Universidad Central de Venezuela, Venezuela

Abstract

ABSTRACT Here the mechanism by which perifosine induced cell death in Leishmania donovani and Leishmania amazonensis is described. The drug reduced Leishmania mitochondrial membrane potential and decreased cellular ATP levels while increasing phosphatidylserine externalization. Perifosine did not increase membrane permeabilization. We also found that the drug inhibited the phosphorylation of Akt in the parasites. These results highlight the potential use of perifosine as an alternative to miltefosine against Leishmania .

Funder

Instituto de Salud Carlos III

Obra Social La Caixa- Fundación CajaCanarias

Ramón y Cajal Subprogramme from the Spanish Ministry of Science an Innovation

Redes Temáticas de Investigación Cooperativa

Fundación Canaria Dr. Manuel Morales

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02127-16