Structural Study of SARS-CoV-2 Antibodies Identifies a Broad-Spectrum Antibody That Neutralizes the Omicron Variant by Disassembling the Spike Trimer-Reference-Cited by-同舟云学术

Structural Study of SARS-CoV-2 Antibodies Identifies a Broad-Spectrum Antibody That Neutralizes the Omicron Variant by Disassembling the Spike Trimer

Published:2022-08-24 Issue:16 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Zhan Wuqiang¹²³,Tian Xiaolong²⁴,Zhang Xiang¹²³,Xing Shenghui¹²³,Song Wenping²⁴,Liu Qianying¹²³,Hao Aihua¹²³,Hu Yuxia¹²³,Zhang Meng¹²³,Ying Tianlei²⁴^ORCID,Chen Zhenguo¹²³,Lan Fei¹²³,Sun Lei¹²³^ORCID

Affiliation:

1. Shanghai Fifth People’s Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, China

2. Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China

3. Shanghai Key Laboratory of Medical Epigenetics, Fudan University, Shanghai, China

4. MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, Shanghai Engineering Research Center for Synthetic Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China

Abstract

The emergence of the Omicron strain of SARS-CoV-2 caused higher immune escape, raising unprecedented concerns about the effectiveness of antibody therapies and vaccines. In this study, we identified a SARS-CoV-2 neutralizing antibody, 553-49, which neutralizes all variants by targeting a completely conserved novel epitope.

Funder

MOST | National Key Research and Development Program of China

Ministry of Science and Technology of the People's Republic of China

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00480-22

Reference38 articles.

1. A new coronavirus associated with human respiratory disease in China