Genetic Characterization of Vga ABC Proteins Conferring Reduced Susceptibility to Pleuromutilins in Staphylococcus aureus-Reference-Cited by-同舟云学术

Genetic Characterization of Vga ABC Proteins Conferring Reduced Susceptibility to Pleuromutilins in Staphylococcus aureus

Published:2008-12 Issue:12 Volume:52 Page:4507-4509
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Gentry Daniel R.¹,McCloskey Lynn¹,Gwynn Michael N.¹,Rittenhouse Stephen F.¹,Scangarella Nicole¹,Shawar Ribhi¹,Holmes David J.¹

Affiliation:

1. Department of Microbiology, ID-CEDD, GlaxoSmithKline, Collegeville, Pennsylvania 19426

Abstract

ABSTRACT Retapamulin MICs of ≥2 μg/ml were noted for 6 of 5,676 S. aureus recent clinical isolates evaluated. The ABC proteins VgaAv and VgaA were found to be responsible for the reduced susceptibility to pleuromutilins exhibited by these six isolates.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00915-08

Reference11 articles.

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