Anti-HIV and Anti-Hepatitis C Virus Drugs Inhibit P-Glycoprotein Efflux Activity in Caco-2 Cells and Precision-Cut Rat and Human Intestinal Slices-Reference-Cited by-同舟云学术

Anti-HIV and Anti-Hepatitis C Virus Drugs Inhibit P-Glycoprotein Efflux Activity in Caco-2 Cells and Precision-Cut Rat and Human Intestinal Slices

Published:2019-11 Issue:11 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Martinec Ondrej¹,Huliciak Martin¹,Staud Frantisek¹,Cecka Filip²,Vokral Ivan¹^ORCID,Cerveny Lukas¹^ORCID

Affiliation:

1. Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic

2. Department of Surgery, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic

Abstract

P-glycoprotein (ABCB1), an ATP-binding-cassette efflux transporter, limits intestinal absorption of its substrates and is a common site of drug-drug interactions (DDIs). ABCB1 has been suggested to interact with many antivirals used to treat HIV and/or chronic hepatitis C virus (HCV) infections.

Funder

Czech Science Foundation

Charles University

EFSA-CDN

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00910-19

Reference85 articles.

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3. Evolving Epidemiology of Hepatitis C Virus in the United States

4. Centers for Disease Control and Prevention. 2019. Hepatitis C kills more Americans than any other infectious disease. https://www.cdc.gov/media/releases/2016/p0504-hepc-mortality.html. Accessed 7 February 2019.

5. Current antiviral drugs and their analysis in biological materials – Part II: Antivirals against hepatitis and HIV viruses

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