Sequence Variation in a Newly Identified HLA-B35-Restricted Epitope in the Influenza A Virus Nucleoprotein Associated with Escape from Cytotoxic T Lymphocytes-Reference-Cited by-同舟云学术

Sequence Variation in a Newly Identified HLA-B35-Restricted Epitope in the Influenza A Virus Nucleoprotein Associated with Escape from Cytotoxic T Lymphocytes

Published:2002-03 Issue:5 Volume:76 Page:2567-2572
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Boon A. C. M.¹,de Mutsert G.¹,Graus Y. M. F.²,Fouchier R. A. M.¹,Sintnicolaas K.³,Osterhaus A. D. M. E.¹,Rimmelzwaan G. F.¹

Affiliation:

1. Institute of Virology, Erasmus University Rotterdam, 3015 GE Rotterdam

2. Numico Research B. V., 6700 CA Wageningen

3. Laboratory for Histocompatibility and Immunogenetics, Bloodbank Rotterdam, 3318 AS Dordrecht, The Netherlands

Abstract

ABSTRACT Here, we describe a new HLA-B*3501-restricted cytotoxic T lymphocyte (CTL) epitope in the influenza A virus (H3N2) nucleoprotein, which was found to exhibit a high degree of variation at nonanchor residues. The influenza virus variants emerged in chronological order, and CTLs directed against old variants failed to recognize more recent strains of influenza A virus, indicating an escape from CTL immunity.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.76.5.2567-2572.2002

Reference35 articles.

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