Enhancement of Hepatitis B Virus Replication by Its X Protein in Transgenic Mice-Reference-Cited by-同舟云学术

Enhancement of Hepatitis B Virus Replication by Its X Protein in Transgenic Mice

Published:2002-03 Issue:5 Volume:76 Page:2579-2584
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Xu Zhenming¹,Yen T. S. Benedict²³,Wu Lanying⁴,Madden Charles R.⁵,Tan Wenjie¹,Slagle Betty L.⁵,Ou Jing-hsiung¹

Affiliation:

1. Department of Molecular Microbiology and Immunology

2. Department of Pathology, University of California

3. Pathology Service, Veterans Affairs Medical Center, San Francisco, California 94121

4. Department of Molecular Biology and Biochemistry, University of Southern California, Los Angeles, California 90033

5. Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030

Abstract

ABSTRACT Hepatitis B virus (HBV) X gene encodes a multifunctional protein that can regulate cellular signaling pathways, interact with cellular transcription factors, and induce hepatocellular oncogenesis. In spite of its diverse activities, the precise role of the X protein in the viral life cycle of HBV remains unclear. To investigate this question, we have produced transgenic mice that carry either the wild-type HBV genome or a mutated HBV genome incapable of expressing the 16.5-kDa X protein. Our results indicate that while the X protein is not absolutely essential for HBV replication or its maturation in transgenic mice, it can enhance viral replication, apparently by activating viral gene expression. These results demonstrate a transactivation role of the X protein in HBV replication in transgenic mice.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.76.5.2579-2584.2002

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