Urinary Bactericidal Activity of Extended-Release Ciprofloxacin (1,000 Milligrams) versus Levofloxacin (500 Milligrams) in Healthy Volunteers Receiving a Single Oral Dose-Reference-Cited by-同舟云学术

Urinary Bactericidal Activity of Extended-Release Ciprofloxacin (1,000 Milligrams) versus Levofloxacin (500 Milligrams) in Healthy Volunteers Receiving a Single Oral Dose

Published:2006-11 Issue:11 Volume:50 Page:3947-3949
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Wagenlehner Florian M. E.¹,Kinzig-Schippers Martina²,Tischmeyer Uwe¹,Wagenlehner Christine¹,Sörgel Fritz²³,Naber Kurt G.¹

Affiliation:

1. Department of Urology, St. Elisabeth Hospital, Straubing

2. Institute for Biomedical and Pharmaceutical Research (IBMP), Nürnberg-Heroldsberg

3. Institute of Pharmacology, University of Essen, Essen, Germany

Abstract

ABSTRACT Twelve volunteers received a single oral dose of 1,000 mg extended-release (XR) ciprofloxacin versus 500 mg levofloxacin to assess urinary bactericidal titers (UBTs) against common uropathogens. Areas under UBT-time curves were significantly larger for Proteus mirabilis with XR ciprofloxacin and for staphylococci with levofloxacin.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00477-06

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