Genome Evolution to Penicillin Resistance in Serotype 3 Streptococcus pneumoniae by Capsular Switching-Reference-Cited by-同舟云学术

Genome Evolution to Penicillin Resistance in Serotype 3 Streptococcus pneumoniae by Capsular Switching

Published:2017-09 Issue:9 Volume:61 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Chiba Naoko¹²,Murayama Somay Y.³,Morozumi Miyuki¹,Iwata Satoshi¹,Ubukata Kimiko¹

Affiliation:

1. Department of Infectious Diseases, Keio University School of Medicine, Tokyo, Japan

2. Department of Bacteriology, Gunma University Graduate School of Medicine, Gunma, Japan

3. Laboratory of Medical Microbiology, Nihon University Graduate School of Pharmacy, Chiba, Japan

Abstract

ABSTRACT Streptococcus pneumoniae isolates of serotype 3 were collected from cases of invasive pneumococcal disease ( n = 124) throughout Japan between April 2010 and March 2013. A penicillin-resistant S. pneumoniae (PRSP) isolate from an adult patient, strain KK0981 of serotype 3, was identified among these strains. Whole-genome analysis characterized this PRSP as a recombinant strain derived from PRSP of serotype 23F with the cps locus (20.3 kb) replaced by that of a penicillin-susceptible strain of serotype 3.

Funder

Ministry of Health, Labour and Welfare

MEXT | Japan Society for the Promotion of Science

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00478-17

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1. Rapid Decrease of 7-Valent Conjugate Vaccine Coverage for Invasive Pneumococcal Diseases in Pediatric Patients in Japan

2. Changes in Capsule and Drug Resistance of Pneumococci after Introduction of PCV7, Japan, 2010–2013