Bronchoalveolar Lavage Fluid Cytology in Culture-Documented Invasive Pulmonary Aspergillosis in Patients with Hematologic Diseases: Analysis of 67 Episodes-Reference-Cited by-同舟云学术

Bronchoalveolar Lavage Fluid Cytology in Culture-Documented Invasive Pulmonary Aspergillosis in Patients with Hematologic Diseases: Analysis of 67 Episodes

Published:2018-10 Issue:10 Volume:56 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Fernández-Cruz A.¹²,Magira E.¹³,Heo S. T.¹⁴,Evans S.⁵,Tarrand J.⁶,Kontoyiannis D. P.¹

Affiliation:

1. Department of Infectious Diseases, Infection Control, and Employee Health, University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA

2. Department of Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain

3. First Department of Critical Care Medicine, Medical School of National and Kapodistrian University of Athens, Evangelismos Hospital, Athens, Greece

4. Department of Internal Medicine, Jeju National University School of Medicine, Jeju, Republic of Korea

5. Department of Pulmonary Medicine, University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA

6. Department of Microbiology, University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA

Abstract

There is a paucity of studies on the yield of Gomori-methenamine-silver (GMS) staining in bronchoalveolar lavage (BAL) fluid cytology and its comparison with fluorescent dye staining for the diagnosis of invasive pulmonary aspergillosis (IPA) in patients with hematologic malignancies. To that end, we analyzed the yield of direct fungal visualization in BAL fluid cytology with GMS staining, in a series of culture-positive IPA cases in 67 patients with hematologic malignancies, and we compared the results with those of direct examination with calcofluor white staining and BAL fluid galactomannan assays, when available.

Funder

Sociedad Española de Enfermedades Infecciosas y Microbiología Médica

Fulbright Foundation

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.00962-18

Reference12 articles.

1. Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline

2. Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America