A Novel Live Attenuated Respiratory Syncytial Virus Vaccine Candidate with Mutations in the L Protein SAM Binding Site and the G Protein Cleavage Site Is Protective in Cotton Rats and a Rhesus Macaque-Reference-Cited by-同舟云学术

A Novel Live Attenuated Respiratory Syncytial Virus Vaccine Candidate with Mutations in the L Protein SAM Binding Site and the G Protein Cleavage Site Is Protective in Cotton Rats and a Rhesus Macaque

Published:2021-01-13 Issue:3 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Jenkins Tiffany¹²^ORCID,Wang Rongzhang¹,Harder Olivia¹,Xue Miaoge¹,Chen Phylip²,Corry Jacqueline³,Walker Christopher²⁴,Teng Michael⁵,Mejias Asuncion²⁴,Ramilo Octavio²⁴,Niewiesk Stefan¹,Li Jianrong¹,Peeples Mark E.²⁴^ORCID

Affiliation:

1. Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA

2. Center for Vaccines and Immunity, Abigail Wexner Research Institute at Nationwide Children’s Hospital, Columbus, Ohio, USA

3. Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

4. Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio, USA

5. Department of Internal Medicine, University of South Florida Morsani College of Medicine, Tampa, Florida, USA

Abstract

Globally, respiratory syncytial virus (RSV) is a major cause of death in children under 1 year of age, yet no vaccine is available. We have generated a novel RSV live attenuated vaccine candidate containing mutations in the L and G proteins.

Funder

Infectious Disease Institute, Ohio State University

HHS | National Institutes of Health

OSU | Center for Clinical and Translational Science, Ohio State University

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01568-20

Reference51 articles.

1. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study

2. Risk of Primary Infection and Reinfection With Respiratory Syncytial Virus

3. Respiratory syncytial virus infection

4. Safety and Pharmacokinetics of Palivizumab Therapy in Children Hospitalized with Respiratory Syncytial Virus Infection

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. SINE RNA of the imprinted miRNA clusters mediates constitutive type III interferon expression and antiviral protection in hemochorial placentas;Cell Host & Microbe;2023-07

2. Respiratory syncytial virus: from pathogenesis to potential therapeutic strategies;International Journal of Biological Sciences;2021