Affiliation:
1. Department of Pathology, Bowman Gray School of Medicine, Winston-Salem, North Carolina 27103
Abstract
The analogue of phenylalanine, β-3-thienylalanine, depresses severely the primary and secondary immune response to sheep erythrocytes in mice when administered for a few days immediately before and after each injection of antigen. For this immunosuppression to occur, animals must be maintained on a phenylalanine-free diet during the times of drug injection since dietary phenylalanine will restore anamnestic response. With these experimental conditions, the number of direct and indirect plaque-forming cells is greatly reduced during immune responses. The finding that marked immunosuppression can be obtained with a very short drug and diet treatment points to a potential usefullness of the analogue as a powerful immunosuppressant.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference10 articles.
1. Use of an antiglobulin serum to detect cells producing antibody with low haemolitic efficiency;Dresser D. W.;Nature (London),1965
2. Effect of p8-3- thienylalanine on antibody synthesis. Ill. Inhibition of RNA and protein synthesis in immunized rat spleens;Hotham-Iglewski B.;Proc. Soc. Exp. Biol. Med.,1969
3. Effect of j3-3-thienylalanine and deoxypiridoxine on growth of the Murphy-Sturm Iymphosarcoma;Hruban Z.;Cancer Res.,1960
4. Jerne N. K. A. A. Nordin and C. Henry. 1963. The agar plaque technique for recognizing antibody producing cells p. 109-125. In B. Amos and H. Koprowski (ed.) Cellbound antibodies. Wistar Institute Press Philadelphia.
5. Effect of,t-3-thienylalanine on antibody synthesis. I. Preliminary in vitro and in vivo studies;La Via M. F.;Proc. Soc. Exp. Biol. Med.,1960
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献