Electron Cryotomography Reveals the Portal in the Herpesvirus Capsid-Reference-Cited by-同舟云学术

Electron Cryotomography Reveals the Portal in the Herpesvirus Capsid

Published:2007-02-15 Issue:4 Volume:81 Page:2065-2068
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Chang Juan T.¹,Schmid Michael F.¹,Rixon Frazer J.²,Chiu Wah¹

Affiliation:

1. Graduate Program in Structural and Computational Biology and Molecular Biophysics, National Center for Macromolecular Imaging, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030

2. MRC Institute of Virology, University of Glasgow, Glasgow G11 5JR, United Kingdom

Abstract

ABSTRACT Herpes simplex virus type 1 is a human pathogen responsible for a range of illnesses from cold sores to encephalitis. The icosahedral capsid has a portal at one fivefold vertex which, by analogy to portal-containing phages, is believed to mediate genome entry and exit. We used electron cryotomography to determine the structure of capsids lacking pentons. The portal vertex appears different from pentons, being located partially inside the capsid shell, a position equivalent to that of bacteriophage portals. Such similarity in portal organization supports the idea of the evolutionary relatedness of these viruses.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02053-06

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