Variations in Strains of Streptomyces griseus Isolated from a Degenerating Streptomycin-Producing Culture

Author:

Nomi Ryosaku1

Affiliation:

1. Institute of Microbiology, Rutgers, The State University, New Brunswick, New Jersey

Abstract

Streptomycin-resistant strains were isolated from a degenerated streptomycin-producing culture of Streptomyces griseus . From 250 resistant strains, 3 low, 2 intermediate, and 2 high potency strains were selected; these were compared in their morphological, cultural, physiological, and streptomycin-producing properties. Though no definite correlation between streptomycin production and the other properties could be obtained, the following correlations were considered as distinct differences among the low, intermediate, and high potency strains. (i) When streptomycin-producing ability degenerates, more submerged spore formation or fragmentation of mycelium into shorter filaments appears to occur. (ii) On agar medium, low and intermediate potency strains often show finely wrinkled growth; high potency strains do not show such characteristics. (iii) High potency strains excrete a distinct yellow soluble pigment on synthetic agar medium and on glucose-yeast extract agar, but low and intermediate potency strains show little or no ability to form this soluble pigment. (iv) In low and intermediate potency strains, inositol and arginine did not stimulate streptomycin production as they did in high potency strains. Streptamine showed some stimulating effect in the high potency strains and, in contrast, a depressive effect in intermediate potency strains, though streptidine showed a distinctly stimulating effect in all groups of strains employed.

Publisher

American Society for Microbiology

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference18 articles.

1. Study of an ultra violet induced mutant no. 100 of Actinomyces streptomycini unable to synthesize streptomycin;ALIKHANIAN S. I.;Mikrobiologiya,1962

2. The production of spores in submerged cultures by some Streptomyces;CARVAJAL F.;Mycologia,1947

3. Estimation of streptomycin in fermentation broth;DOERY H. M.;Anal. Chem.,1950

4. Process for production of streptomycin;DULANEY E. L.;U. S. Patent,1951

5. The effect of compound containing a guanidine group and of inositol on the biosynthesis of streptomycin;EGOROV N. S.;Antibiotiki,1959

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