Disrupting Gram-Negative Bacterial Outer Membrane Biosynthesis through Inhibition of the Lipopolysaccharide Transporter MsbA-Reference-Cited by-同舟云学术

Disrupting Gram-Negative Bacterial Outer Membrane Biosynthesis through Inhibition of the Lipopolysaccharide Transporter MsbA

Published:2018-11 Issue:11 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Alexander Mary Kate¹,Miu Anh²,Oh Angela³,Reichelt Mike⁴,Ho Hoangdung³,Chalouni Cecile⁴,Labadie Sharada⁵,Wang Lan⁵,Liang Jun⁵,Nickerson Nicholas N.¹,Hu Huiyong⁵,Yu Lan⁶,Du Miaofen⁶,Yan Donghong⁷,Park Summer⁷,Kim Janice⁷,Xu Min⁷,Sellers Benjamin D.⁵,Purkey Hans E.⁵,Skelton Nicholas J.⁵,Koehler Michael F. T.⁵,Payandeh Jian³,Verma Vishal⁵,Xu Yiming²,Koth Christopher M.³,Nishiyama Mireille¹

Affiliation:

1. Genentech, Inc., Infectious Diseases, South San Francisco, California, USA

2. Genentech, Inc., Biochemical and Cellular Pharmacology, South San Francisco, California, USA

3. Genentech, Inc., Structural Biology, South San Francisco, California, USA

4. Genentech, Inc., Pathology, South San Francisco, California, USA

5. Genentech, Inc., Discovery Chemistry, South San Francisco, California, USA

6. WuXi AppTec Co. Ltd., Shanghai, China

7. Genentech, Inc., Translational Immunology, South San Francisco, California, USA

Abstract

There is a critical need for new antibacterial strategies to counter the growing problem of antibiotic resistance. In Gram-negative bacteria, the outer membrane (OM) provides a protective barrier against antibiotics and other environmental insults.

Funder

Genentech

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01142-18

Reference58 articles.

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5. Mechanism of Assembly of the Outer Membrane of Salmonella typhimurium

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