A New Application of MALDI Biotyper for a Potential Use in Therapeutic Drug Monitoring of Voriconazole-Reference-Cited by-同舟云学术

A New Application of MALDI Biotyper for a Potential Use in Therapeutic Drug Monitoring of Voriconazole

Published:2021-07-16 Issue:8 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Falces-Romero Iker¹^ORCID,Mingorance Jesús¹^ORCID,García-Rodríguez Julio¹,Cendejas-Bueno Emilio¹

Affiliation:

1. Clinical Microbiology and Parasitology Department, Hospital Universitario La Paz, IdiPaz, Madrid, Spain

Abstract

We present a proof-of-concept study on the use of MALDI Biotyper to detect and monitor the levels of voriconazole in human serum. A simple extraction-concentration method and a MALDI Biotyper protocol were developed, and a parent ion of voriconazole (1 H + ) could be detected and quantified with good reproducibility. Our results point to a new application of MALDI Biotyper for therapeutic drug monitoring.

Funder

MEC | Instituto de Salud Carlos III

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02458-20

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