Affiliation:
1. Hospital del Niño, Panama City, Panama.
Abstract
Ninety infants and children were prospectively randomized to receive cefepime (n = 43) or cefotaxime (n = 47) for therapy of bacterial meningitis. The two treatment groups were comparable in terms of age, duration of illness before enrollment, history of seizures, clinical status on admission, and etiology. Six (7%) patients died--two treated with cefepime and four treated with cefotaxime. Clinical response, cerebrospinal fluid sterilization, development of complications, antibiotic toxicity, and hospital stay were similar for the two treatment regimens. Concentrations of cefepime in cerebrospinal fluid varied from 55 to 95 times greater than the maximal MIC required by the causative pathogens. Audiologic and/or neurologic sequelae were found in 16% of the cefepime-treated patients and 15% of the cefotaxime-treated patients examined 2 to 6 months after discharge. We conclude that cefepime is safe and therapeutically equivalent to cefotaxime for management of bacterial meningitis in infants and children.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference13 articles.
1. Outcomes of bacterial meningitis in children: a meta-analysis;Baraff L. J.;Pediatr. Infect. Dis. J.,1993
2. Estudio abierto y aleatorio diseado para comparar la seguridad y eficacia entre cefepime, cefotaxime y ampicilinacloramfenicol en el tratamiento de la meningitis bacteriana en nios;Castao E.;Bol. Soc. Panamea Pediatr.,1993
3. Diagnosis and management of meningitis;Feigin R. D.;Pediatr. Infect. Dis. J.,1992
4. Comparison of a new cephalosporin;Kessler R. E.;Antimicrob. Agents Chemother.,1985
5. Efficacy of BMY-28142 in experimental bacteremia and meningitis caused by Escherichia coli and group B streptococci;Kim K. S.;Antimicrob. Agents Chemother.,1985
Cited by
118 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献