Susceptibilities of Legionella spp. to Newer Antimicrobials In Vitro-Reference-Cited by-同舟云学术

Susceptibilities of Legionella spp. to Newer Antimicrobials In Vitro

Published:1998-06 Issue:6 Volume:42 Page:1520-1523
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Schülin T.¹²,Wennersten C. B.¹,Ferraro M. J.²³,Moellering R. C.¹²,Eliopoulos G. M.¹²

Affiliation:

1. Department of Medicine, West Campus, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215,1

2. Harvard Medical School, Boston, Massachusetts 02115,2 and

3. Massachusetts General Hospital, Boston, Massachusetts 021143

Abstract

ABSTRACT The in vitro activities of 13 antimicrobial agents against 30 strains of Legionella spp. were determined. Rifapentine, rifampin, and clarithromycin were the most potent agents (MICs at which 90% of isolates are inhibited [MIC 90 s], ≤0.008 μg/ml). The ketolide HMR 3647 and the fluoroquinolones levofloxacin and BAY 12-8039 (MIC 90 s, 0.03 to 0.06 μg/ml) were more active than erythromycin A or roxithromycin. The MIC 90 s of dalfopristin-quinupristin and linezolid were 0.5 and 8 μg/ml, respectively. Based on class characteristics and in vitro activities, several of these agents may have potential roles in the treatment of Legionella infections.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.42.6.1520

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