Molecular Epidemiological and Phylogenetic Associations of Two Novel Putative Virulence Genes, iha and iroN E. coli , among Escherichia coli Isolates from Patients with Urosepsis

Author:

Johnson James R.1,Russo Thomas A.2,Tarr Phillip I.3,Carlino Ulrike2,Bilge Sima S.3,Vary James C.3,Stell Adam L.1

Affiliation:

1. Medical Service, VA Medical Center, and Department of Medicine, University of Minnesota, Minneapolis, Minnesota1;

2. Medical Service, VA Medical Center, and Department of Medicine and Center for Microbial Pathogenesis, State University of New York at Buffalo, Buffalo, New York2; and

3. Division of Gastroenterology, Children's Hospital and Regional Medical Center, and Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington3

Abstract

ABSTRACT Two novel putative Escherichia coli virulence genes, iha and iroN from E. coli ( iroN E. coli ), were detected in 55 and 39%, respectively, of 67 E. coli isolates from patients with urosepsis. iha and iroN E. coli exhibited divergent associations with other putative virulence genes, phylogenetic markers, host characteristics, and antimicrobial resistance.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference30 articles.

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4. Donnenberg M. S. Welch R. A. Virulence determinants of uropathogenic Escherichia coli. In H. L. T. Mobley and J. W. Warren (ed.) Urinary tract infections: molecular pathogenesis and clinical management. 1996 ASM Press Washington D.C.

5. The spectrum of infections and pathogenic mechanisms of Escherichia coli;Eisenstein B. I.;Adv. Intern. Med.,1988

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