The Metalloproteinase Inhibitor GI5402 Inhibits Endotoxin-Induced Soluble CD27 and CD16 Release in Healthy Humans-Reference-Cited by-同舟云学术

The Metalloproteinase Inhibitor GI5402 Inhibits Endotoxin-Induced Soluble CD27 and CD16 Release in Healthy Humans

Published:2000-05 Issue:5 Volume:68 Page:3036-3039
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Dekkers Pascale E. P.¹,ten Hove Tessa¹,Lauw Fanny N.¹,Koene Harry R.²,Lumley Philip³,van Deventer Sander J. H.¹,van der Poll Tom¹

Affiliation:

1. Laboratory of Experimental Internal Medicine, Academic Medical Center,1 and

2. Laboratory of Experimental and Clinical Immunology, Central Laboratory of The Netherlands Red Cross Blood Transfusion Service,2 University of Amsterdam, Amsterdam, The Netherlands, and

3. Department of Clinical Pharmacology, Glaxo Wellcome, Greenford, United Kingdom3

Abstract

ABSTRACT Metalloproteinases have been implicated in the cleavage of a number of cell surface immune receptors. Oral administration of the metalloproteinase inhibitor GI5402 attenuated the release of soluble CD27 and CD16 into the circulation after intravenous endotoxin injection in healthy humans.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.68.5.3036-3039.2000

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