Increased Levels of Soluble Fas Ligand in Serum in Plasmodium falciparum Malaria-Reference-Cited by-同舟云学术

Increased Levels of Soluble Fas Ligand in Serum in Plasmodium falciparum Malaria

Published:2000-05 Issue:5 Volume:68 Page:3061-3063
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Kern Peter¹,Dietrich Manfred²,Hemmer Christoph²,Wellinghausen Nele¹

Affiliation:

1. Section of Infectious Diseases and Clinical Immunology, University of Ulm, Ulm,1 and

2. Clinical Department, Bernhard Nocht Institute for Tropical Medicine, Hamburg,2 Germany

Abstract

ABSTRACT Levels of soluble Fas ligand (sFasL) in serum were elevated in patients with Plasmodium falciparum malaria and showed a significant decline during disease course. sFasL levels that were elevated before antimalarial treatment began correlated significantly with depressed total lymphocyte and T-cell counts. These data suggest that Fas-induced apoptosis might play a role in malaria-associated lymphopenia.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.68.5.3061-3063.2000

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