Role of Gamma Interferon and Interleukin-4 in Host Defense against the Human Filarial Parasite Brugia malayi-Reference-Cited by-同舟云学术

Role of Gamma Interferon and Interleukin-4 in Host Defense against the Human Filarial Parasite Brugia malayi

Published:2000-05 Issue:5 Volume:68 Page:3034-3035
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Babu Subash¹,Ganley Lisa M.¹,Klei Thomas R.²,Shultz Leonard D.³,Rajan T. V.¹

Affiliation:

1. Department of Pathology, University of Connecticut Health Center, Farmington, Connecticut 06030-31051;

2. Department of Veterinary Microbiology and Parasitology, Louisiana State University, Baton Rouge, Louisiana 70803-84162; and

3. The Jackson Laboratory, Bar Harbor, Maine 046093

Abstract

ABSTRACT We have investigated the roles of gamma interferon (IFN-γ) and interleukin-4 (IL-4) in host defense against Brugia malayi . Our data suggest that the lack of either IFN-γ or IL-4 prolongs the time required to achieve sterile immunity, suggesting that both canonical type 1 and type 2 responses are involved in the clearance of infection.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.68.5.3034-3035.2000

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