Depressed CD40 Ligand Expression Contributes to Reduced Gamma Interferon Production in Human Tuberculosis-Reference-Cited by-同舟云学术

Depressed CD40 Ligand Expression Contributes to Reduced Gamma Interferon Production in Human Tuberculosis

Published:2000-05 Issue:5 Volume:68 Page:3002-3006
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Samten Buka¹,Thomas Elaine K.²,Gong Jianhua¹,Barnes Peter F.¹³⁴

Affiliation:

1. Center for Pulmonary and Infectious Disease Control1 and

2. Immunex Corporation, Seattle, Washington 981012

3. Departments of Cell Biology3 and

4. Medicine,4 University of Texas Health Center, Tyler, Texas 75710, and

Abstract

ABSTRACT Expression of CD40 ligand (CD40L) correlated directly with Mycobacterium tuberculosis -stimulated gamma interferon (IFN-γ) production by peripheral blood mononuclear cells (PBMC) from tuberculosis patients and healthy tuberculin reactors. The CD40L agonist increased M. tuberculosis -induced IFN-γ production by PBMC, and anti-CD40 or anti-CD40L antibodies reduced IFN-γ production. CD40L expression on PBMC was reduced by exposure to B cells and to soluble factors from M. tuberculosis -infected monocytes. These findings suggest that CD40L dysregulation contributes to reduced IFN-γ production in human tuberculosis.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.68.5.3002-3006.2000

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