Immune Profiling To Predict Outcome of Clostridioides difficile Infection-Reference-Cited by-同舟云学术

Immune Profiling To Predict Outcome of Clostridioides difficile Infection

Published:2020-06-30 Issue:3 Volume:11 Page:
ISSN:2161-2129
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Abhyankar Mayuresh M.¹,Ma Jennie Z.²,Scully Kenneth W.³,Nafziger Andrew J.¹,Frisbee Alyse L.¹,Saleh Mahmoud M.¹,Madden Gregory R.¹,Hays Ann R.⁴,Poulter Mendy⁵,Petri William A.¹^ORCID

Affiliation:

1. Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia, USA

2. Division of Biostatistics, Department of Public Health Sciences, University of Virginia Health System, Charlottesville, Virginia, USA

3. Department of Public Health Sciences, University of Virginia Health System, Charlottesville, Virginia, USA

4. Division of Gastroenterology and Hepatology, Department of Medicine, University of Virginia Health System, Charlottesville, Virginia, USA

5. Department of Pathology, University of Virginia Health System, Charlottesville, Virginia, USA

Abstract

Clostridioides difficile infection is the most common health care-associated infection in the United States with more than 20% patients experiencing symptomatic recurrence. The complex nature of host-bacterium interactions makes it difficult to predict the course of the disease based solely on clinical parameters. In the present study, we built a robust prediction model using representative plasma biomarkers and clinical parameters for 90-day all-cause mortality. Risk prediction based on immune biomarkers and clinical variables may contribute to treatment selection for patients as well as provide insight into the role of immune system in C. difficile pathogenesis.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.00905-20

Reference47 articles.

1. Current Status of Clostridium difficile Infection Epidemiology

2. Centers for Disease Control and Prevention. 2020. Clostridioides difficile fact sheet. Centers for Disease Control and Prevention Atlanta GA. https://www.cdc.gov/drugresistance/pdf/threats-report/clostridioides-difficile-508.pdf. Accessed 13 March 2020.

3. Clostridium difficileassociated risk of death score (CARDS): a novel severity score to predict mortality among hospitalised patients withC. difficileinfection

4. Treatment of recurrent Clostridium difficile colitis: a narrative review

5. Clostridium diffcile associated infection, diarrhea andcolitis

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