Normal Values for CD4 and CD8 Lymphocyte Subsets in Healthy Chinese Adults from Shanghai-Reference-Cited by-同舟云学术

Normal Values for CD4 and CD8 Lymphocyte Subsets in Healthy Chinese Adults from Shanghai

Published:2004-07 Issue:4 Volume:11 Page:811-813
ISSN:1556-6811
Container-title:Clinical and Vaccine Immunology
language:en
Short-container-title:Clin Vaccine Immunol

Author:

Jiang Weiming¹²³,Kang Laiyi¹²³,Lu Hong-Zhou¹²³,Pan Xiaozhang¹²³,Lin Qingneng¹²³,Pan Qichao¹²³,Xue Yile¹²³,Weng Xinhua¹²³,Tang Yi-Wei¹²³

Affiliation:

1. Department of Infectious Diseases, Fudan University Huashan Hospital

2. Municipal AIDS Research Center, Shanghai Centers for Disease Control and Prevention, Shanghai, China

3. Departments of Medicine and Pathology, Vanderbilt University Medical Center, Nashville, Tennessee

Abstract

ABSTRACT The aim of this study was to establish reference ranges for lymphocyte subsets in Chinese adults. Venous blood specimens were obtained from 614 healthy, human immunodeficiency virus (HIV)-seronegative adults in Shanghai. Flow cytometry was used to determine percentages and absolute numbers of CD4 and CD8 T lymphocytes. Mean values for CD4 and CD8 lymphocytes were 727 and 540 cells/μl, respectively, yielding a CD4/CD8 ratio of 1.49. While CD8 lymphocyte values varied with age and gender, no significant differences in CD4 lymphocyte values were observed. Shanghai adults had approximately 100 fewer CD4 lymphocytes/μl on average than Caucasians, suggesting that lower CD4 lymphocyte cutoffs for classifying and monitoring HIV infection may be needed in China.

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

Link

https://journals.asm.org/doi/pdf/10.1128/CDLI.11.4.811-813.2004

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