Affiliation:
1. Servizio di Virologia, IRCCS Policlinico San Matteo, 27100 Pavia, Italy
Abstract
ABSTRACT
Clinical evaluation of a novel fully automated chemiluminescence immunoassay for determination of immunoglobulin G avidity to human cytomegalovirus (HCMV) showed 92.8% sensitivity and 84.7% specificity in detecting a recent (≤90 days) primary HCMV infection. The assay appears useful for accurately diagnosing recent primary HCMV infections.
Publisher
American Society for Microbiology
Subject
Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy
Reference14 articles.
1. Blackburn, N. K., T. G. Besselaar, B. D. Schoub, and K. F. O'Connell. 1991. Differentiation of primary cytomegalovirus infection from reactivation using the urea denaturation test for measuring antibody avidity. J. Med. Virol.33:6-9.
2. Bodéus, M., D. Beulné, and P. Goubau. 2001. Ability of three IgG-avidity assays to exclude recent cytomegalovirus infection. Eur. J. Clin. Microbiol. Infect. Dis.20:248-252.
3. Bodéus, M., M. Van Ranst, P. Bernard, C. Hubinont, and P. Goubau. 2002. Anticytomegalovirus IgG avidity in pregnancy: a 2-year prospective study. Fetal Diagn. Ther.17:362-366.
4. Fowler, K. B., S. Stagno, R. F. Pass, W. J. Britt, T. J. Boll, and C. A. Alford. 1992. The outcome of congenital cytomegalovirus infection in relation to maternal antibody status. N. Engl. J. Med.326:663-667.
5. Standardization of the Human Cytomegalovirus Antigenemia Assay by Means of In Vitro-Generated pp65-Positive Peripheral Blood Polymorphonuclear Leukocytes
Cited by
21 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献