Deep Sequencing of H7N9 Influenza A Viruses from 16 Infected Patients from 2013 to 2015 in Shanghai Reveals Genetic Diversity and Antigenic Drift-Reference-Cited by-同舟云学术

Deep Sequencing of H7N9 Influenza A Viruses from 16 Infected Patients from 2013 to 2015 in Shanghai Reveals Genetic Diversity and Antigenic Drift

Published:2018-10-31 Issue:5 Volume:3 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Xiao Yong-Li¹,Ren Lili²,Zhang Xi³,Qi Li¹,Kash John C.¹,Xiao Yan²,Wu Fan³,Wang Jianwei²,Taubenberger Jeffery K.¹

Affiliation:

1. Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

2. MOH Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China

3. Shanghai Municipal Center for Disease Control and Prevention, Shanghai, People’s Republic of China

Abstract

H7N9 subtype avian influenza viruses caused infections in over 1,400 humans from 2013 to 2017 and resulted in almost 600 deaths. It is important to understand how avian influenza viruses infect and cause disease in humans and to assess their potential for efficient person-to-person transmission. In this study, we used deep sequencing of primary clinical material to assess the evolution and potential for human adaptation of H7N9 influenza viruses.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Chinese Academy of Medical Sciences

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphereDirect.00462-18

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1. Influenza Virus Evolution, Host Adaptation, and Pandemic Formation

2. Pandemic Influenza’s 500th Anniversary