Affiliation:
1. Institute of Biochemistry, Goethe-University Frankfurt , Frankfurt, Germany
Abstract
ABSTRACT
In a recent study by Inga V. Leus, Sean R. Roberts, Anhthu Trinh, Edward W. Yu, and Helen I. Zgurskaya (J Bacteriol, 2023,
https://doi.org/10.1128/jb.00217-23
), it was found that the clinically relevant resistance–nodulation–cell division (RND)-type AdeABC antibiotic efflux pump from
Acinetobacter baumannii
exhibits close communication between its antibiotic binding sites. Alterations in one of them can have far-reaching impacts on the drug translocation pathway. These insights could reshape our understanding of RND-type efflux pump mechanisms.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
2 articles.
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