Building Optimal Three-Drug Combination Chemotherapy Regimens To Eradicate Mycobacterium tuberculosis in Its Slow-Growth Acid Phase

Author:

Kim Sarah1ORCID,Yamada Walter M.2,Duncanson Brandon3,Nole Jocelyn3,Rogers Stephanie3,Parker Sarah3,Bacci Meredith3,Mtchedlidze Nino3,Peloquin Charles A.4ORCID,Louie Arnold3ORCID,Schmidt Stephan1,Drusano George L.3ORCID,Neely Michael N.2ORCID

Affiliation:

1. Center for Pharmacometrics and Systems Pharmacology, Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, Florida, USA

2. Laboratory of Applied Pharmacokinetics and Bioinformatics and Division of Pediatric Infectious Diseases, Children’s Hospital of Los Angeles, Los Angeles, California, USA

3. Institute for Therapeutic Innovation, College of Medicine, University of Florida, Orlando, Florida, USA

4. Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, Florida, USA

Abstract

Mycobacterium tuberculosis metabolic state affects the response to therapy. Quantifying the effect of antimicrobials in the acid and nonreplicating metabolic phases of M. tuberculosis growth will help to optimize therapy for tuberculosis.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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