High-Level Expression of NRAMP1 in Peripheral Blood Cells and Tuberculous Granulomas from Mycobacterium bovis -Infected Bovines-Reference-Cited by-同舟云学术

High-Level Expression of NRAMP1 in Peripheral Blood Cells and Tuberculous Granulomas from Mycobacterium bovis -Infected Bovines

Published:2001-11 Issue:11 Volume:69 Page:7165-7168
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Estrada-Chávez Ciro¹²,Pereira-Suárez Ana L.²,Meraz Marco A.²,Arriaga Camila¹,Garcı́a-Carrancá Alejandro³,Sánchez-Rodriguez Cristina⁴,Mancilla Raúl⁴

Affiliation:

1. Centro Nacional de Investigación Disciplinaria en Microbiologı́a, INIFAP, Palo Alto, Mexico City, 05110,1

2. Departamento de Biomedicina Molecular, Centro de Investigaciones y de Estudios Avanzados, IPN, San Pedro Zacatenco, Mexico City, 07360,2 and

3. Departamento de Biologı́a Molecular3 and

4. Departamento de Immunologı́a, Instituto de Investigaciones Biomédicas,4 UNAM, Mexico City, 04510, Mexico

Abstract

ABSTRACT By Western blotting, we demonstrate high-level expression of NRAMP1 proteins in peripheral blood cells and granulomas of Mycobacterium bovis -infected bovines. Immunohistochemistry of granulomatous lesions showed heavily labeled epithelioid macrophages and Langhans cells. These data suggest that M. bovis infection enhances NRAMP1 expression and that active tuberculosis can occur despite this response.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.69.11.7165-7168.2001

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