Affiliation:
1. Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223
Abstract
ABSTRACT
Little is known about the underlying mechanisms that result in a sexually dimorphic response to
Vibrio vulnificus
endotoxic shock.
V. vulnificus
is a gram-negative bacterium, considered one of the most invasive and rapidly fatal human pathogens known. However, 85% of individuals that develop endotoxic shock from
V. vulnificus
are males. Using the rat, we have developed a model for
V. vulnificus
endotoxic shock that mimics the sexually dimorphic response in humans. Gonadectomy in females results in increased mortality, and estrogen replacement results in decreased mortality in both gonadectomized males and females. These results demonstrate that estrogen is providing protection against
V. vulnificus
lipopolysaccharide-induced endotoxic shock.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
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