Urethral Cytokine and Immune Responses in Chlamydia trachomatis -Infected Males

Author:

Pate Mitchell S.12,Hedges Spencer R.2,Sibley Don A.2,Russell Michael W.2,Hook Edward W.23,Mestecky Jiri14

Affiliation:

1. Department of Microbiology1 and

2. Division of Infectious Diseases2 and

3. Department of Medicine, The University of Alabama at Birmingham, and Jefferson County Department of Health,3Birmingham, Alabama 35294

4. Division of Clinical Immunology and Rheumatology,4

Abstract

ABSTRACT Penile urethral swabs collected from PCR-confirmed Chlamydia trachomatis -infected, C. trachomatis -uninfected, and non- C. trachomatis -infected, nongonococcal urethritis-infected males were analyzed for cytokine, total immunoglobulin (Ig), and specific antibody levels by enzyme-linked immunosorbent assay. Differential cellular components of the swab transport medium were also enumerated for the same groups. Although low, the levels of C. trachomatis -specific IgA and IgG antibodies and interleukin 8 cytokine were significantly higher in C. trachomatis -infected individuals. There were no significant differences in the levels of seven additional cytokines evaluated.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference29 articles.

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5. Tissue distribution of antileukoprotease and lysozyme in humans;Franken C.;J. Histochem. Cytochem.,1989

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