Author:
Ichise K,Tanio T,Saji I,Okuda T
Abstract
The antifungal activity of orally active SM-4470, (R)-3-(n-butylthio)-2-(2,4-dichlorophenyl)-1-(imidazole-1-yl)-2-propanol hydrochloride, was compared with that of ketoconazole. SM-4470 showed twofold-higher activity than ketoconazole in the oral treatment of systemic infection with Candida albicans in mice. In addition, SM-4470 was effective against aspergillosis in mice, but ketoconazole was ineffective. The efficacy of SM-4470 was similar to that of ketoconazole in curing experimental candidal vaginitis in rats and trichophytosis in guinea pigs, although its serum concentrations in these animals were lower than those of ketoconazole. These data suggest that SM-4470 may be of value in the treatment of both systemic and superficial fungal infections in humans.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference12 articles.
1. Nephrotoxicity of amphotericin B with emphasis on changes in tubular function;Burgess J. L.;Am. J. Med.,1972
2. Current status of griseofulvin;Goldman L.;J. Am. Med. Assoc.,1960
3. Heel R. C. 1982. Ketoconazole: in vitro and in vivo activity p. 57-66. In H. B. Levine (ed.) Ketoconazole in the management of fungal disease. Adis Press New York
4. Ketoconazole: a review of its therapeutic efficacy in superficial and systemic fungal infections;Heel R. C.;Drugs,1982
5. Recent developments in antimycotic chemotherapy;Holts R. J.;Infection,1974
Cited by
7 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献