Are Standard Dosing Regimens of Ceftriaxone Adapted for Critically Ill Patients with Augmented Creatinine Clearance?-Reference-Cited by-同舟云学术

Are Standard Dosing Regimens of Ceftriaxone Adapted for Critically Ill Patients with Augmented Creatinine Clearance?

Published:2019-03 Issue:3 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Ollivier Julien¹,Carrié Cédric²,d’Houdain Nicolas¹,Djabarouti Sarah¹³,Petit Laurent²,Xuereb Fabien¹³⁴,Legeron Rachel¹³⁴,Biais Matthieu²⁴,Breilh Dominique¹³⁴

Affiliation:

1. Pharmacy and Clinical Pharmacy Department, CHU Bordeaux, Bordeaux, France

2. Anesthesiology and Critical Care Department, CHU Bordeaux, Bordeaux, France

3. Pharmacokinetics and PK/PD Group, INSERM 1034, Université Bordeaux, Bordeaux, France

4. Université Bordeaux Segalen, Bordeaux, France

Abstract

The objective of the present study was to determine whether augmented renal clearance (ARC) impacts negatively on ceftriaxone pharmacokinetic (PK)/pharmacodynamic (PD) target attainment in critically ill patients. Over a 9-month period, all critically ill patients treated with ceftriaxone were eligible.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02134-18

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