Affiliation:
1. Laboratory Service, Veterans Administration Medical Center, Buffalo, New York 14215.
Abstract
The activities of fluoroquinolones and a new macrolide against 30 clinical isolates of Mycobacterium tuberculosis were determined in vitro by agar diffusion. In order of relative potencies against M. tuberculosis, temafloxacin (MIC for 90% of isolates [MIC90], 2.3 micrograms/ml) was at least as active as the reference quinolones ofloxacin (MIC90, 2.4 micrograms/ml) and ciprofloxacin (MIC90, 4.3 micrograms/ml). Less active were difloxacin (MIC90, 4.7 micrograms/ml), pefloxacin (MIC90, 6.7 micrograms/ml), and enoxacin (MIC90, 8.3 micrograms/ml). The macrolide clarithromycin was more potent than erythromycin but less potent than the fluoroquinolones. Our results suggest that the newer fluoroquinolones and clarithromycin should be included with ciprofloxacin and ofloxacin in pharmacokinetic studies that may lead to trials in human subjects with mycobacterial infections.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference13 articles.
1. Ciprofloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use;Campoli-Richards D. M.;Drugs,1988
2. In vitro susceptibility of mycobacteria to ciprofloxacin;Collins C. H.;J. Antimicrob. Chemother.,1985
3. Comparative in vitro activities of ciprofloxacin and other 4-quinolones against Mycobacterium tuberculosis and Mycobacterium intracellulare;Fenlon C. H.;Antimicrob. Agents Chemother.,1986
4. In vitro and in vivo evaluation of A-56268 (TE-031), a new macrolide;Fernandes P. B.;Antimicrob. Agents Chemother.,1986
5. In vitro activities of norfloxacin and ciprofloxacin against Mycobacterium tuberculosis, M. avium complex, M. chelonei, M. fortuitum, and M. kansasii;Gay J. D.;Antimicrob. Agents Chemother.,1984
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