Affiliation:
1. Department of Pharmacy Practice, College of Pharmacy, University of Utah, Salt Lake City 84112.
Abstract
To detect a change in antibiotic susceptibility patterns in Pseudomonas aeruginosa isolates upon the introduction and clinical use of ciprofloxacin, aztreonam, and ceftazidime, MICs for clinical isolates collected before introduction of the antibiotics, during early clinical use, and later were determined for these and seven other antipseudomonal antibiotics. Concomitant resistance to two or more antibiotics was also studied. Over the three study periods, rates of susceptibility to 9 of the 10 antibiotics decreased. The largest decrease occurred with ceftazidime. Analysis of subsets of isolates from patients treated with ciprofloxacin or aztreonam also showed declining susceptibility to the latter but a stabilization of susceptibility to the former after an initial decline. Concomitant resistance within and among antibiotic classes was common.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference17 articles.
1. Absence of rapidly developing resistance during treatment of cystic fibrosis patients with aztreonam;Allen J. E.;Diagn. Microbiol. Infect. Dis.,1987
2. In vitro activities of aztreonam, piperacillin, and ticarcillin combined with amikacin against amikacin-resistant Pseudomonas aeruginosa and P. cepacia isolates from children with cystic fibrosis;Aronoff S. C.;Antimicrob. Agents Chemother.,1984
3. Antimicrobial susceptibility of Pseudomonas from sputum of patients;Blessing J.;Monogr. Paediatr.,1981
4. Controlled trial of aztreonam vs. tobramycin and azlocillin for acute pulmonary exacerbations of cystic fibrosis;Bosso J. A.;Pediatr. Infect. Dis. J.,1988
5. Bosso J. A. P. G. Black and J. M. Matsen. 1987. Ciprofloxacin versus tobramycin plus azlocillin in pulmonary exacerbations in adults with cystic fibrosis. Am. J. Med. 82(Suppl. 4A):180-184.
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