In vitro bone marrow toxicity of nucleoside analogs against human immunodeficiency virus-Reference-Cited by-同舟云学术

In vitro bone marrow toxicity of nucleoside analogs against human immunodeficiency virus

Published:1989-04 Issue:4 Volume:33 Page:576-579
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Inoue T¹,Tsushita K¹,Itoh T¹,Ogura M¹,Hotta T¹,Saneyoshi M¹,Yoshida S¹,Saitoh H¹,Tomoda Y¹,Nagai Y¹

Affiliation:

1. Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Japan.

Abstract

3'-Azido-2',3'-dideoxythymidine is known to cause severe anemia and neutropenia. Although these are rare for 2',3'-dideoxycytidine, it frequently impairs thrombocytogenesis. These differential myelossuppressive features correlated well with the in vitro toxicities of the drugs for a megakaryoblastic cell line and for colony formation of erythroid and granulocytic cells.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.33.4.576

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