False-Positive Results for Human Immunodeficiency Virus Type 1 Nucleic Acid Amplification Testing in Chimeric Antigen Receptor T Cell Therapy-Reference-Cited by-同舟云学术

False-Positive Results for Human Immunodeficiency Virus Type 1 Nucleic Acid Amplification Testing in Chimeric Antigen Receptor T Cell Therapy

Published:2019-12-23 Issue:1 Volume:58 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Hauser Jocelyn R.¹,Hong Hong¹,Babady N. Esther¹^ORCID,Papanicolaou Genovefa A.²,Tang Yi-Wei¹³^ORCID

Affiliation:

1. Department of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA

2. Department of Internal Medicine, Memorial Sloan Kettering Cancer Center, Weill Medical College of Cornell University, New York, New York, USA

3. Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, New York, USA

Abstract

Chimeric antigen receptor (CAR) T cell immunotherapy has been a major advancement in cancer therapeutics. Reprogramming of T cells is achieved by using gammaretroviral or lentiviral vectors, which may interfere with human immunodeficiency virus type 1 (HIV-1) nucleic acid amplification testing (NAAT).

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.01420-19

Reference9 articles.

1. Engineering CAR-T cells

2. Clinical use of lentiviral vectors

3. False-Positive HIV PCR Test Following Ex Vivo Lentiviral Gene Transfer Treatment of X-linked Severe Combined Immunodeficiency Vector