Author:
Pouplin Thomas,Pouplin Julie Nguyen,Van Toi Pham,Lindegardh Niklas,Rogier van Doorn H.,Hien Tran Tinh,Farrar Jeremy,Török M. Estée,Chau Tran Thi Hong
Abstract
ABSTRACTThe recommended treatment for herpes simplex encephalitis (HSE) remains intravenous acyclovir. In resource-poor countries, however, intravenous formulations are usually unavailable or unaffordable. We report the penetration of acyclovir into the cerebrospinal fluid (CSF) in patients with HSE, treated with the oral prodrug valacyclovir at 1,000 mg three times daily. The oral therapy achieved adequate acyclovir concentrations in the CSF and may be an acceptable early treatment for suspected HSE in resource-limited settings.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
53 articles.
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