FoxA2 Involvement in Suppression of Protein C, an Outcome Predictor in Experimental Sepsis-Reference-Cited by-同舟云学术

FoxA2 Involvement in Suppression of Protein C, an Outcome Predictor in Experimental Sepsis

Published:2006-03 Issue:3 Volume:13 Page:426-432
ISSN:1556-6811
Container-title:Clinical and Vaccine Immunology
language:en
Short-container-title:Clin Vaccine Immunol

Author:

Berg David T.¹,Gerlitz Bruce¹,Sharma Ganesh R.¹,Richardson Mark A.¹,Stephens Eddie J.²,Grubbs Renee L.²,Holmes Kimberly C.²,Fynboe Kelly²,Montani Dominick²,Cramer Martin S.¹,Engle Steven D.¹,Jakubowski Joseph A.¹,Heuer Josef G.¹,Grinnell Brian W.¹

Affiliation:

1. Biotechnology Discovery Research

2. Pharmacology Core, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285

Abstract

ABSTRACT Low levels of protein C (PC) predict outcome as early as 10 h after insult in a rat polymicrobial sepsis model and were associated with suppression of PC mRNA, upstream transcription factor FoxA2, and cofactor hepatocyte nuclear factor 6 (HNF6). Small interfering RNA suppression of FoxA2 in isolated hepatocytes demonstrated regulation of both its cofactor HNF6 and PC. Our data suggest that reduced FoxA2 may be important in the suppression of PC and resulting poor outcome in sepsis.

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

Link

https://journals.asm.org/doi/pdf/10.1128/CVI.13.3.426-432.2006

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