Affiliation:
1. Department of Chemistry and Biochemistry, Old Dominion University , Norfolk, Virginia, USA
Abstract
ABSTRACT
The intestinal pathogen
Clostridioides difficile
encodes roughly 50 TCS, but very few have been characterized in terms of their activating signals or their regulatory roles. A. G. Pannullo, B. R. Zbylicki, and C. D. Ellermeier (J Bacteriol 205:e00164-23, 2023,
https://doi.org/10.1128/jb.00164-23
) have identified both for the novel
C. difficile
TCD DraRS. DraRS responds to antibiotics that target lipid-II molecules in the bacterial cell envelope, and regulates the production of a novel glycolipid necessary for bacitracin and daptomycin resistance in
C. difficile
.
Funder
National Science Foundation
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology