Ebolavirus VP35 Interacts with the Cytoplasmic Dynein Light Chain 8-Reference-Cited by-同舟云学术

Ebolavirus VP35 Interacts with the Cytoplasmic Dynein Light Chain 8

Published:2009-07 Issue:13 Volume:83 Page:6952-6956
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Kubota Toru¹²,Matsuoka Mayumi³²,Chang Tsung-Hsien²,Bray Mike⁴,Jones Steven⁵,Tashiro Masato¹,Kato Atsushi¹,Ozato Keiko²

Affiliation:

1. Department of Virology III

2. Laboratory of Molecular Growth Regulation, Genomics of Differentiation Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-2753

3. Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, Tokyo 208-0011, Japan

4. Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892

5. Population and Public Health Branch, National Microbiology Laboratory, Canadian Science Centre for Human and Animal Health, Manitoba R3E 3R2, Canada

Abstract

ABSTRACT The viral protein VP35 of ebolavirus (EBOV) is implicated to have diverse roles in the viral life cycle. We employed a yeast two-hybrid screen to search for VP35 binding partners and identified the cytoplasmic dynein light chain (DLC8) as a protein that interacts with VP35. Mapping analysis unraveled a consensus motif, SQTQT, within VP35 through which VP35 binds to DLC8. The disruption of DLC8 binding does not affect the ability of VP35 to inhibit type I IFN production. Given that VP35 from various EBOV species interacts with DLC8, this interaction may have a role in regulating the EBOV life cycle.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00480-09

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