Comparative Antibody Responses to the Live-Attenuated and Recombinant Herpes Zoster Vaccines

Author:

Schmid D. Scott1ORCID,Miao Congrong1,Leung Jessica1,Johnson Michael2,Weinberg Adriana234,Levin Myron J.23

Affiliation:

1. Viral Vaccine Preventable Diseases Branch, Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

2. Department of Pediatrics, University of Colorado Denver School of Medicine, Anschutz Medical Campus, Aurora, Colorado, USA

3. Department of Medicine, University of Colorado Denver School of Medicine, Anschutz Medical Campus, Aurora, Colorado, USA

4. Department of Pathology, University of Colorado Denver School of Medicine, Anschutz Medical Campus, Aurora, Colorado, USA

Abstract

These observations further distinguish the immunogenicity and duration of the immune response of the two vaccines. In addition, measurements of functional humoral immunity (IgG avidity and neutralizing antibody) in response to zoster immunization, alone or combined with other immune markers, might contribute to practical in vitro correlates of protection.

Funder

HHS | Centers for Disease Control and Prevention

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Reference54 articles.

1. Levin MJ. 2017. Zoster vaccine, p 1268–1281. In Plotkin S, Orenstein W, Offitt P, Edwards KM (ed), Vaccines, 7th ed. Elsevier, Philadelphia, PA.

2. Levin MJ, Schmader KS, Oxman MN. 2019. Chapter 165. Varicella and herpes zoster, p 3035–3064. In Kang S, Amagai M, Bruckner AL, Enk AH, Margolis DJ, McMichael AJ, Orringer JS (ed), Fitzpatrick’s dermatology, 9th ed. McGraw-Hill Education, New York, NY.

3. Incidence of herpes zoster in patients with altered immune function

4. Cellular and Humoral Immunity in the Pathogenesis of Recurrent Herpes Viral Infections in Patients with Lymphoma

5. Influence of Age and Nature of Primary Infection on Varicella‐Zoster Virus–Specific Cell‐Mediated Immune Responses

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