Modulation of the CCR5 Receptor/Ligand Axis by Seminal Plasma and the Utility of In Vitro versus In Vivo Models-Reference-Cited by-同舟云学术

Modulation of the CCR5 Receptor/Ligand Axis by Seminal Plasma and the Utility of In Vitro versus In Vivo Models

Published:2019-06 Issue:11 Volume:93 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Juno Jennifer A.¹^ORCID,Wragg Kathleen M.¹,Kristensen Anne B.¹,Lee Wen Shi¹,Selva Kevin J.¹,van der Sluis Renee M.²,Kelleher Anthony D.³,Bavinton Benjamin R.³,Grulich Andrew E.³,Lewin Sharon R.²⁴,Kent Stephen J.¹⁵⁶^ORCID,Parsons Matthew S.¹

Affiliation:

1. Department of Microbiology and Immunology, the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia

2. The Peter Doherty Institute for Infection and Immunity, Royal Melbourne Hospital, Melbourne, Victoria, Australia

3. The Kirby Institute, UNSW Sydney, Sydney, New South Wales, Australia

4. Department of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, Australia

5. Melbourne Sexual Health Centre and Infectious Disease Department, Alfred Hospital, Monash University Central Clinical School, Melbourne, Victoria, Australia

6. ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, The University of Melbourne, Melbourne, Victoria, Australia

Abstract

The majority of HIV-1 vaccine studies do not take into consideration the impact that semen exposure might have on the mucosal immune system. In this study, we demonstrate that seminal plasma (SP) exposure can alter CCR5 expression on T cells. Importantly, in vitro studies of T cells in culture cannot replicate the conditions under which immune cells might be recruited to the genital mucosa in vivo , leading to potentially erroneous conclusions about the impact of semen on mucosal HIV-1 susceptibility.

Funder

Department of Health | National Health and Medical Research Council

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00242-19

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