Production of Interferon in Mice: Effect of Altered Gaseous Environments

Author:

Huang Kun-Yen1,Gordon Francis B.1

Affiliation:

1. Department of Microbiology, Naval Medical Research Institute, Bethesda, Maryland 20014

Abstract

Effects of altered gaseous environments (parabarosis) on interferon production in mice were studied, with Newcastle disease virus (NDV) as the inducer. Increased levels of interferon in lung tissue were observed when mice were exposed to 11% O 2 in N 2 for 3 days before and after, or only after, injection of NDV. However, serum interferon levels remained unchanged. Exposure of mice to 77% O 2 for up to 7 days did not affect the response to interferon induction as assayed in lungs or sera. Interferon levels were significantly depressed in mice exposed to a simulated depth of 213 ft in seawater [with normal partial pressure of O 2 (pO 2 ) in N 2 ] for 2 or 4 weeks. Whereas definite depression of interferon was also observed in mice maintained at a simulated altitude of 37,000 ft (with normal pO 2 ) for 2 weeks, those maintained at the same condition for 4 weeks showed a normal level of interferon. The results obtained with hypoxia are compatible with other reports on the influence of O 2 tension on viral infection. The factors responsible for alterations observed in interferon level in mice kept in normal pO 2 , but under altered pressure, have not yet been identified.

Publisher

American Society for Microbiology

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference23 articles.

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3. Role of interferon during viremia. II. Productive action of circulating interferon;Baron S.;J. Immunol.,1966

4. Rack permitting efficient handling of tissue cultures;Baron S.;Appl. Microbiol.,1966

5. Influence of simulated altitude on resistance-susceptibility to S. typhimurium infection in mice;Berry L. J.;Texas Rept. Biol. Med.,1953

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