Detection of Circulating Aspergillus fumigatus Galactomannan: Value and Limits of the Platelia Test for Diagnosing Invasive Aspergillosis

Author:

Pinel Claudine1,Fricker-Hidalgo Hélène1,Lebeau Bernadette1,Garban Frédéric2,Hamidfar Rébecca3,Ambroise-Thomas Pierre1,Grillot Renée1

Affiliation:

1. Service de Parasitologie-Mycologie

2. Département de Cancérologie

3. Département de Médecine Aïgue Spécialisée, Centre Hospitalier Universitaire, 38043 Grenoble, France

Abstract

ABSTRACT The effectiveness of galactomannan detection with the Platelia test was evaluated in a prospective study of 3,327 sera from 807 patients. The specificity was 99.6% (748 of 751 cases). For the groups of patients with proven and probable invasive aspergillosis, the sensitivity was 50.0% (17 of 34 cases). The disappointing sensitivity associated with the presence of rare false-positive cases underlines the limits of this test.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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