Model-Informed Clinical Practice - Determining an Appropriate Ampicillin-Sulbactam Redosing Regimen in Surgical Patients by Utilizing Population Pharmacokinetics and Target Attainment Analysis-Reference-Cited by-同舟云学术

Model-Informed Clinical Practice - Determining an Appropriate Ampicillin-Sulbactam Redosing Regimen in Surgical Patients by Utilizing Population Pharmacokinetics and Target Attainment Analysis

Published:2023-04-18 Issue:4 Volume:67 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Reeder Joshua A.¹,O’Sullivan Cormac T.²,Xu Min¹,Wu Nan¹,Ince Dilek³,Rogers William K.⁴,An Guohua¹^ORCID

Affiliation:

1. Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, Iowa, USA

2. College of Nursing, University of Iowa Hospital and Clinics, Iowa City, Iowa, USA

3. Department of Internal Medicine, Division of Infectious Diseases, Carver College of Medicine, University of Iowa Hospital and Clinics, Iowa City, Iowa, USA

4. Department of Anesthesia, University of Minnesota Medical School, Minneapolis, Minnesota, USA

Abstract

In the current study, population pharmacokinetic (PK) of ampicillin-sulbactam was performed based on the clinical pharmacokinetics data collected from a prospective study conducted in 40 surgical patients undergoing prolonged surgery where antibiotic redosing was implemented. A population PK model was successfully developed to characterize the disposition of ampicillin and sulbactam.

Funder

Internal funding source

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.01248-22

Reference31 articles.

1. Estimating Health Care-Associated Infections and Deaths in U.S. Hospitals, 2002

2. Prevalence of Healthcare-Associated Infections in Acute Care Hospitals in Jacksonville, Florida

3. Surgical site infection following abdominal surgery: a prospective cohort study

4. Ampicillin/Sulbactam

5. Sulbactam/Ampicillin

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